MSA1/YOR066W Summary

MSA1 BASIC INFORMATION

Standard Name	MSA1 1
Systematic Name	YOR066W
Alias	YOR29-17
Feature Type	ORF, Verified
Description	Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation (1, 2, 3)
Name Description	Mbf and Sbf Associated 1

GO Annotations	All MSA1 GO evidence and references
	View Computational GO annotations for MSA1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	G1/S transition of mitotic cell cycle (IMP) regulation of cell size (IGI, IMP) regulation of transcription involved in G1 phase of mitotic cell cycle (IMP, IPI)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Mutant Phenotype	All MSA1 Phenotype details and references
Classical genetics
null	resistance to rapamycin: increased
overexpression	budding: abnormal cell cycle progression in G1 phase: abnormal cell cycle progression in S phase: abnormal cellular morphology: abnormal critical cell size at START (G1 cell-size checkpoint): decreased
repressible	critical cell size at START (G1 cell-size checkpoint): increased
Large-scale survey
null	viable
overexpression	vegetative growth: decreased

Interactions	MSA1 All interactions details and references
	19 total interaction(s) for 14 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 1 Affinity Capture-Western: 4 Biochemical Activity: 2 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 3 Synthetic Growth Defect: 4 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 1

Sequence Information

ChrXV:449438 to 451327 | |

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1890	449438..451327	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005592

MSA1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MSA1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MSA1]

1)	Ashe M, et al. (2008) The SBF- and MBF-associated Protein Msa1 Is Required for Proper Timing of G1-specific Transcription in Saccharomyces cerevisiae. J Biol Chem 283(10):6040-9
2)	Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
3)	Kosugi S, et al. (2009) Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs. Proc Natl Acad Sci U S A 106(25):10171-6

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