CKA2/YOR061W Summary Help

Standard Name CKA2
Systematic Name YOR061W
Alias YOR29-12
Feature Type ORF, Verified
Description Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching (1, 2, 3, 4, 5)
Name Description Casein Kinase Alpha' subunit
Gene Product Alias CK2 subunit 1
Chromosomal Location
ChrXV:441534 to 442553 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CKA2 GO evidence and references
  View Computational GO annotations for CKA2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
419 total interaction(s) for 267 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 166
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 13
  • Biochemical Activity: 29
  • Co-purification: 1
  • PCA: 6
  • Reconstituted Complex: 3
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Growth Defect: 6
  • Dosage Lethality: 1
  • Dosage Rescue: 9
  • Negative Genetic: 72
  • Phenotypic Enhancement: 7
  • Phenotypic Suppression: 16
  • Positive Genetic: 72
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 3
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 339
Molecular Weight (Da) 39,403
Isoelectric Point (pI) 8.84
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:441534 to 442553 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1020 441534..442553 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005587
References cited on this page View Complete Literature Guide for CKA2
1) Padmanabha R, et al.  (1990) Isolation, sequencing, and disruption of the yeast CKA2 gene: casein kinase II is essential for viability in Saccharomyces cerevisiae. Mol Cell Biol 10(8):4089-99
2) Ackermann K, et al.  (2001) Genes targeted by protein kinase CK2: a genome-wide expression array analysis in yeast. Mol Cell Biochem 227(1-2):59-66
3) Ahmed K, et al.  (2002) Joining the cell survival squad: an emerging role for protein kinase CK2. Trends Cell Biol 12(5):226-30
4) Li J, et al.  (2012) Regulation of Budding Yeast Mating-Type Switching Donor Preference by the FHA Domain of Fkh1. PLoS Genet 8(4):e1002630
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76