TMC1/YOR052C Summary Help

Standard Name TMC1 1
Systematic Name YOR052C
Alias YOR29-03
Feature Type ORF, Verified
Description AN1-type zinc finger protein of unknown function; may protect cells from trivalent metalloid induced proteotoxicity; contains a PACE promoter element, a transcriptional profile similar to CUZ1 and RPN2, and decreased expression in an RPN4 mutant; induced by nitrogen limitation and weak acid; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5, 6, 7)
Name Description Trivalent Metalloid sensitive, Cuz1-related protein 1
Chromosomal Location
ChrXV:427224 to 426772 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All TMC1 GO evidence and references
  View Computational GO annotations for TMC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Regulators 14 genes
Classical genetics
Large-scale survey
18 total interaction(s) for 17 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 5
  • Protein-RNA: 1

Genetic Interactions
  • Negative Genetic: 4
  • Positive Genetic: 2
  • Synthetic Lethality: 1

Expression Summary
Length (a.a.) 150
Molecular Weight (Da) 16,734
Isoelectric Point (pI) 9.85
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXV:427224 to 426772 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..453 427224..426772 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005578
References cited on this page View Complete Literature Guide for TMC1
1) Hanna J, et al.  (2014) Cuz1/Ynl155w, a Zinc-dependent Ubiquitin-binding Protein, Protects Cells from Metalloid-induced Proteotoxicity. J Biol Chem 289(3):1876-85
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Schuller C, et al.  (2004) Global phenotypic analysis and transcriptional profiling defines the weak acid stress response regulon in Saccharomyces cerevisiae. Mol Biol Cell 15(2):706-20
4) Scherens B, et al.  (2006) Identification of direct and indirect targets of the Gln3 and Gat1 activators by transcriptional profiling in response to nitrogen availability in the short and long term. FEMS Yeast Res 6(5):777-91
5) Brohee S, et al.  (2011) Unraveling networks of co-regulated genes on the sole basis of genome sequences. Nucleic Acids Res 39(15):6340-58
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
7) Sa-Moura B, et al.  (2013) A Conserved Protein with AN1 Zinc Finger and Ubiquitin-like Domains Modulates Cdc48 (p97) Function in the Ubiquitin-Proteasome Pathway. J Biol Chem 288(47):33682-96