Standard Name	CKB2
Systematic Name	YOR039W
Feature Type	ORF, Verified
Description	Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase (1, 2, 3)
Name Description	Casein Kinase Beta' subunit
Gene Product Alias	CK2 subunit 4

Chromosomal Location	ChrXV:405768 to 406544 | ORF Map | GBrowse

	View Computational GO annotations for CKB2
Molecular Function
Manually curated	protein kinase regulator activity (IMP, IPI) protein serine/threonine kinase inhibitor activity (IDA)
Biological Process
Manually curated	protein phosphorylation (IDA, IMP) regulation of transcription from RNA polymerase I promoter (IDA) regulation of transcription from RNA polymerase III promoter (IDA) response to DNA damage stimulus (IDA)
Cellular Component
Manually curated	CURI complex (IDA) protein kinase CK2 complex (IDA) UTP-C complex (IDA)

Classical genetics
null	ionic stress resistance: decreased vegetative growth: decreased rate
Large-scale survey
null	UV resistance: decreased alkaline pH resistance: decreased inositol excretion: increased competitive fitness: decreased dessication resistance: decreased freeze-thaw resistance: decreased heat sensitivity: increased hyperosmotic stress resistance: decreased lipid particle morphology: abnormal resistance to amiodarone: decreased resistance to sulfanilamide: decreased resistance to cycloheximide: increased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to sodium arsenite: increased resistance to cycloheximide: decreased resistance to neomycin: decreased resistance to ethanol: decreased resistance to 5-fluorouracil: decreased resistance to dihydromotuporamine C: decreased resistance to arsenite(3-): decreased resistance to caffeine: decreased resistance to fenpropimorph: decreased resistance to hydroxyurea: decreased resistance to sodium selenide: decreased resistance to dimethyl sulfoxide: decreased resistance to chloroquine: decreased resistance to methyl methanesulfonate: decreased resistance to tunicamycin: increased resistance to sirolimus: decreased resistance to doxorubicin: decreased stress resistance: increased transposable element transposition: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	471 total interaction(s) for 267 unique genes/features.
Physical Interactions	Affinity Capture-MS: 102 Affinity Capture-RNA: 3 Affinity Capture-Western: 6 Biochemical Activity: 10 Co-purification: 1 PCA: 5 Reconstituted Complex: 3 Two-hybrid: 5
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 2 Negative Genetic: 250 Phenotypic Enhancement: 4 Phenotypic Suppression: 1 Positive Genetic: 46 Synthetic Growth Defect: 26 Synthetic Lethality: 4 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:405768 to 406544 | ORF Map | GBrowse
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..777 405768..406544 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005565