CYC2/YOR037W Summary Help

Standard Name CYC2
Systematic Name YOR037W
Feature Type ORF, Verified
Description Mitochondrial peripheral inner membrane protein; contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p) (1, 2, 3, 4)
Name Description CYtochrome C
Chromosomal Location
ChrXV:401555 to 402655 | ORF Map | GBrowse
Gbrowse
Genetic position: 12 cM
Gene Ontology Annotations All CYC2 GO evidence and references
  View Computational GO annotations for CYC2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Large-scale survey
null
Resources
95 total interaction(s) for 72 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1
  • Co-purification: 1
  • PCA: 2
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 73
  • Phenotypic Enhancement: 2
  • Positive Genetic: 1
  • Synthetic Growth Defect: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 366
Molecular Weight (Da) 42,368
Isoelectric Point (pI) 10.42
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:401555 to 402655 | ORF Map | GBrowse
SGD ORF map
Genetic position: 12 cM
Last Update Coordinates: 2006-01-05 | Sequence: 2003-09-22
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1101 401555..402655 2006-01-05 2003-09-22
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005563
References cited on this page View Complete Literature Guide for CYC2
1) Pearce DA, et al.  (1998) Cyc2p is required for maintaining ionic stability and efficient cytochrome c import and mitochondrial function in Saccharomyces cerevisiae. FEBS Lett 439(3):307-11
2) Sanchez NS, et al.  (2001) Requirements of Cyc2p and the porin, Por1p, for ionic stability and mitochondrial integrity in Saccharomyces cerevisiae. Arch Biochem Biophys 392(2):326-32
3) Bernard DG, et al.  (2003) Overlapping specificities of the mitochondrial cytochrome c and c1 heme lyases. J Biol Chem 278(50):49732-42
4) Bernard DG, et al.  (2005) Cyc2p, a membrane-bound flavoprotein involved in the maturation of mitochondrial c-type cytochromes. J Biol Chem 280(48):39852-9