AKR2/YOR034C Summary Help

Standard Name AKR2 1
Systematic Name YOR034C
Feature Type ORF, Verified
Description Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication (1, 2)
Name Description AnKyrin Repeat-containing protein 1
Chromosomal Location
ChrXV:397086 to 394837 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All AKR2 GO evidence and references
  View Computational GO annotations for AKR2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 134 genes
Resources
Classical genetics
overexpression
Large-scale survey
null
overexpression
Resources
24 total interaction(s) for 19 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Two-hybrid: 6

Genetic Interactions
  • Negative Genetic: 11
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 749
Molecular Weight (Da) 85,235
Isoelectric Point (pI) 6.72
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:397086 to 394837 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2250 397086..394837 2006-01-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005560
References cited on this page View Complete Literature Guide for AKR2
1) Givan SA and Sprague GF Jr  (1997) The ankyrin repeat-containing protein Akr1p is required for the endocytosis of yeast pheromone receptors. Mol Biol Cell 8(7):1317-27
2) Valdez-Taubas J and Pelham H  (2005) Swf1-dependent palmitoylation of the SNARE Tlg1 prevents its ubiquitination and degradation. EMBO J 24(14):2524-32