SLG1/YOR008C Summary Help

Standard Name SLG1 1
Systematic Name YOR008C
Alias HCS77 , WSC1
Feature Type ORF, Verified
Description Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response (2, 3, 4, 5)
Name Description Synthetic Lethal with Gap 6
Chromosomal Location
ChrXV:342414 to 341278 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SLG1 GO evidence and references
  View Computational GO annotations for SLG1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 123 genes
Resources
Classical genetics
null
overexpression
unspecified
Large-scale survey
null
overexpression
unspecified
Resources
173 total interaction(s) for 125 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Co-fractionation: 2
  • PCA: 1
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Growth Defect: 4
  • Dosage Lethality: 2
  • Dosage Rescue: 44
  • Negative Genetic: 56
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 7
  • Positive Genetic: 11
  • Synthetic Growth Defect: 11
  • Synthetic Lethality: 18
  • Synthetic Rescue: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 378
Molecular Weight (Da) 39,270
Isoelectric Point (pI) 4.52
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:342414 to 341278 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1137 342414..341278 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005534
References cited on this page View Complete Literature Guide for SLG1
1) Lussier M, et al.  (1997) Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae. Genetics 147(2):435-50
2) Lodder AL, et al.  (1999) Characterization of the Wsc1 protein, a putative receptor in the stress response of Saccharomyces cerevisiae. Genetics 152(4):1487-99
3) Gualtieri T, et al.  (2004) The cell wall sensor Wsc1p is involved in reorganization of actin cytoskeleton in response to hypo-osmotic shock in Saccharomyces cerevisiae. Yeast 21(13):1107-20
4) Nanduri J and Tartakoff AM  (2001) The arrest of secretion response in yeast: signaling from the secretory path to the nucleus via Wsc proteins and Pkc1p. Mol Cell 8(2):281-9
5) Mao K, et al.  (2011) Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae. J Cell Biol 193(4):755-67
6) de Bettignies G, et al.  (1999) RGD1 genetically interacts with MID2 and SLG1, encoding two putative sensors for cell integrity signalling in Saccharomyces cerevisiae. Yeast 15(16):1719-31