Standard Name	SPO21
Systematic Name	YOL091W
Alias	MPC70
Feature Type	ORF, Verified
Description	Component of the meiotic outer plaque of the spindle pole body; involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation; SPO21 has a paralog, YSW1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	SPOrulation 5

Chromosomal Location	ChrXV:145334 to 147163 | ORF Map | GBrowse

	View Computational GO annotations for SPO21
Molecular Function
Manually curated	structural molecule activity (IDA, IMP)
Biological Process
Manually curated	ascospore wall assembly (IMP) meiosis (TAS)
Cellular Component
Manually curated	spindle pole body (IDA)

Classical genetics
null	chromosome/plasmid maintenance: abnormal sporulation: absent viable
Large-scale survey
null	competitive fitness: decreased haploinsufficient nutrient utilization: decreased resistance to acetic acid: decreased resistance to Azaserine: increased resistance to polymyxin B: increased resistance to Loperamide: increased resistance to 1,10-phenanthroline: increased resistance to zinc chloride: increased resistance to copper(2+) sulfate: increased resistance to tetraethylammonium chloride: increased resistance to 2,2'-bipyridine: increased resistance to amitrole: decreased resistance to cycloheximide: decreased resistance to hexadecylphosphocholine: increased spore wall formation: absent sporulation: absent sporulation: abnormal sporulation efficiency: decreased toxin resistance: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	74 total interaction(s) for 62 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Biochemical Activity: 6 FRET: 4 Two-hybrid: 57
Genetic Interactions	Dosage Lethality: 1 Phenotypic Enhancement: 2 Synthetic Growth Defect: 2 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:145334 to 147163 | ORF Map | GBrowse
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1830 145334..147163 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005451