Standard Name	BRX1 1
Systematic Name	YOL077C
Feature Type	ORF, Verified
Description	Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif (1, 2, 3, 4)
Name Description	Xenopus laevis Brix (Biogenesis of Ribosomes in Xenopus) homolog 1

Chromosomal Location	ChrXV:186723 to 185848 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for BRX1
Molecular Function
Manually curated	5S rRNA binding (IPI) rRNA primary transcript binding (IPI)
Biological Process
Manually curated	ribosomal large subunit assembly (IPI)
Cellular Component
Manually curated	nucleolus (IPI) preribosome, large subunit precursor (IDA)
High-throughput	preribosome, large subunit precursor (IDA)

Classical genetics
null	dessication resistance: increased
Large-scale survey
conditional	heat sensitivity: increased
null	filamentous growth: increased haploinsufficient inviable
reduction of function	competitive fitness: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	210 total interaction(s) for 115 unique genes/features.
Physical Interactions	Affinity Capture-MS: 154 Affinity Capture-RNA: 2 Affinity Capture-Western: 7 Biochemical Activity: 2 Co-fractionation: 1 PCA: 12 Reconstituted Complex: 1 Two-hybrid: 6
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 6 Positive Genetic: 13 Synthetic Growth Defect: 1 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:186723 to 185848 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2006-01-05 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..876 186723..185848 2006-01-05 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005437