Standard Name	GPD2
Systematic Name	YOL059W
Alias	GPD3
Feature Type	ORF, Verified
Description	NAD-dependent glycerol 3-phosphate dehydrogenase; expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1; GPD2 has a paralog, GPD1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	Glycerol-3-Phosphate Dehydrogenase 1

Chromosomal Location	ChrXV:217126 to 218448 | ORF Map | GBrowse

	View Computational GO annotations for GPD2
Molecular Function
Manually curated	glycerol-3-phosphate dehydrogenase [NAD+] activity (IMP)
Biological Process
Manually curated	glycerol metabolic process (IMP) NADH oxidation (IMP)
Cellular Component
Manually curated	cytosol (TAS) mitochondrion (IDA)
High-throughput	mitochondrion (IDA)

Pathways	glycerol biosynthesis phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) superpathway of phosphatidate biosynthesis

Classical genetics
null	anaerobic growth: decreased rate viable
Large-scale survey
null	anaerobic growth: decreased auxotrophy competitive fitness: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	59 total interaction(s) for 48 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 2 Biochemical Activity: 2 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 4 Negative Genetic: 7 Phenotypic Enhancement: 4 Phenotypic Suppression: 1 Positive Genetic: 12 Synthetic Growth Defect: 7 Synthetic Lethality: 1 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:217126 to 218448 | ORF Map | GBrowse
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1323 217126..218448 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005420