YNR048W Summary Help

Systematic Name YNR048W
Alias CRF1 1
Feature Type ORF, Verified
Description Protein that interacts with phospholipid translocase (flippase) Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication (2, 3, 4, 5)
Chromosomal Location
ChrXIV:711630 to 712811 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YNR048W GO evidence and references
  View Computational GO annotations for YNR048W
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant phenotypes All YNR048W Phenotype evidence and references
Classical genetics
null
Large-scale survey
null
overexpression
Resources
interactions All YNR048W Interaction evidence and references
33 total interaction(s) for 27 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Two-hybrid: 3
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 3
  • Negative Genetic: 8
  • Positive Genetic: 7
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 4
Resources
Expression Summary
histogram
Resources
Protein Information All YNR048W Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:711630 to 712811 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1182 711630..712811 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005331

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
CRF1Nomenclature conflictCRF1 has been used to refer to both YDR223W, whose gene product is involved in transcription regulation, and YNR048W, whose gene product is involved in phospholipid translocation.
References cited on this page View Complete Literature Guide for
1) Saito K, et al.  (2004) Cdc50p, a protein required for polarized growth, associates with the Drs2p P-type ATPase implicated in phospholipid translocation in Saccharomyces cerevisiae. Mol Biol Cell 15(7):3418-32
2) Katoh Y and Katoh M  (2004) Identification and characterization of CDC50A, CDC50B and CDC50C genes in silico. Oncol Rep 12(4):939-43
3) Paulusma CC and Oude Elferink RP  (2005) The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease. Biochim Biophys Acta 1741(1-2):11-24
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Lenoir G, et al.  (2009) Cdc50p plays a vital role in the ATPase reaction cycle of the putative aminophospholipid transporter drs2p. J Biol Chem 284(27):17956-67