FPK1/YNR047W Summary Help

FPK1 BASIC INFORMATION

Standard Name FPK1 1
Systematic Name YNR047W
Feature Type ORF, Verified
Description Ser/Thr protein kinase that regulates the putative phospholipid translocases Lem3p-Dnf1p/Dnf2p; phosphorylates and inhibits upstream inhibitory kinase, Ypk1p; localizes to the cytoplasm, early endosome/TGN compartments, and plasma membrane (1, 2, 3, 4)
Name Description FliPase Kinase 1 1
GO Annotations All FPK1 GO evidence and references
    View Computational GO annotations for FPK1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All FPK1 Phenotype details and references
Classical genetics
null
reduction of function
unspecified
Large-scale survey
null
Interactions FPK1 All interactions details and references
41 total interaction(s) for 38 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 16
  • Protein-RNA: 1
  • Two-hybrid: 1
Genetic Interactions
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 12
  • Synthetic Rescue: 2
Sequence Information
ChrXIV:708526 to 711207 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2010-01-05 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2682 708526..711207 2010-01-05 1997-01-28
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005330

FPK1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for FPK1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for FPK1]

1) Nakano K, et al.  (2008) Protein kinases Fpk1p and Fpk2p are novel regulators of phospholipid asymmetry. Mol Biol Cell 19(4):1783-97
2) Burchett SA, et al.  (2001) Identification of novel pheromone-response regulators through systematic overexpression of 120 protein kinases in yeast. J Biol Chem 276(28):26472-8
3) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
4) Roelants FM, et al.  (2010) A protein kinase network regulates the function of aminophospholipid flippases. Proc Natl Acad Sci U S A 107(1):34-9