AGA1/YNR044W Summary

AGA1/YNR044W Summary

Standard Name	AGA1
Systematic Name	YNR044W
Feature Type	ORF, Verified
Description	Anchorage subunit of a-agglutinin of a-cells; highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds; AGA1 has a paralog, FIG2, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	a cell-specific sexual AGglutination
Gene Product Alias	a-agglutinin anchorage subunit 1

Chromosomal Location	ChrXIV:703699 to 705876 \| ORF Map \| GBrowse

	Genetic position: 42 cM

Gene Ontology Annotations All AGA1 GO evidence and references

	View Computational GO annotations for AGA1
Molecular Function
Manually curated	cell adhesion molecule binding (IMP, ISS)
Biological Process
Manually curated	agglutination involved in conjugation with cellular fusion (IMP)
Cellular Component
Manually curated	fungal-type cell wall (IDA)

Mutant phenotypes All AGA1 Phenotype evidence and references

Classical genetics
null	mating efficiency: decreased viable
unspecified	liquid culture appearance: abnormal
Large-scale survey
null	competitive fitness: increased heat sensitivity: increased starvation resistance: decreased toxin resistance: decreased viable
Resources	PROPHECY \| SCMD \| ScreenTroll \| Yeast Fitness Database

interactions All AGA1 Interaction evidence and references

	27 total interaction(s) for 24 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 Affinity Capture-Western: 1 Protein-RNA: 1
Genetic Interactions	Negative Genetic: 16 Phenotypic Enhancement: 2 Phenotypic Suppression: 1 Synthetic Lethality: 3 Synthetic Rescue: 1
Resources	BioGRID \| BOND \| BioPIXIE \| CYC2008 (complexes) \| Complexome \| DRYGIN \| GeneMANIA \| InterologFinder

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Protein Information All AGA1 Protein evidence and references

Localization	YeastRC \| YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP \| YeastRC
Homologs	Ashbya (AGD) \| Fungal Orthogroups Repository \| P-POD \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrXIV:703699 to 705876 | |

SGD ORF map

: 42 cM

Last Update

Coordinates: 2011-02-03 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2178	703699..705876	2011-02-03	1997-01-28

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP at NCBI \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000005327

References cited on this page View Complete Literature Guide for AGA1

1)	Roy A, et al. (1991) The AGA1 product is involved in cell surface attachment of the Saccharomyces cerevisiae cell adhesion glycoprotein a-agglutinin. Mol Cell Biol 11(8):4196-206
2)	de Nobel H, et al. (1995) Genetics of a-agglutunin function in Saccharomyces cerevisiae. Mol Gen Genet 247(4):409-15
3)	Zhao H, et al. (2001) Interaction of alpha-agglutinin and a-agglutinin, Saccharomyces cerevisiae sexual cell adhesion molecules. J Bacteriol 183(9):2874-80
4)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61