HUB1/YNR032C-A Summary Help

Standard Name HUB1 1
Systematic Name YNR032C-A
Feature Type ORF, Verified
Description Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear (1, 2, 3, 4)
Name Description Homologous to UBiquitin
Chromosomal Location
ChrXIV:687464 to 687243 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All HUB1 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
84 total interaction(s) for 51 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 6
  • Co-crystal Structure: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 44
  • Positive Genetic: 1
  • Synthetic Growth Defect: 23

Resources
Expression Summary
histogram
Resources
Length (a.a.) 73
Molecular Weight (Da) 8,272
Isoelectric Point (pI) 6.52
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:687464 to 687243 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1999-07-17
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..222 687464..687243 2011-02-03 1999-07-17
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000007251
References cited on this page View Complete Literature Guide for HUB1
1) Dittmar GA, et al.  (2002) Role of a ubiquitin-like modification in polarized morphogenesis. Science 295(5564):2442-6
2) McNally T, et al.  (2003) Structural analysis of UBL5, a novel ubiquitin-like modifier. Protein Sci 12(7):1562-6
3) Luders J, et al.  (2003) The ubiquitin-like protein HUB1 forms SDS-resistant complexes with cellular proteins in the absence of ATP. EMBO Rep 4(12):1169-74
4) Mishra SK, et al.  (2011) Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing. Nature ()