POP3/YNL282W Summary Help

Standard Name POP3 1
Systematic Name YNL282W
Feature Type ORF, Verified
Description Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia (1, 2, 3, 4, 5)
Name Description Processing Of Precursor RNAs 1
Chromosomal Location
ChrXIV:107687 to 108274 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All POP3 GO evidence and references
  View Computational GO annotations for POP3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 97 genes
Resources
Classical genetics
null
Large-scale survey
conditional
null
reduction of function
Resources
55 total interaction(s) for 29 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 21
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 15
  • Co-purification: 1
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 10
  • Positive Genetic: 1
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 195
Molecular Weight (Da) 22,612
Isoelectric Point (pI) 10.35
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:107687 to 108274 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..588 107687..108274 2005-11-07 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005226
References cited on this page View Complete Literature Guide for POP3
1) Dichtl B and Tollervey D  (1997) Pop3p is essential for the activity of the RNase MRP and RNase P ribonucleoproteins in vivo. EMBO J 16(2):417-29
2) Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90
3) Houser-Scott F, et al.  (2002) Interactions among the protein and RNA subunits of Saccharomyces cerevisiae nuclear RNase P. Proc Natl Acad Sci U S A 99(5):2684-9
4) Marvin MC, et al.  (2011) Accumulation of noncoding RNA due to an RNase P defect in Saccharomyces cerevisiae. RNA 17(8):1441-50
5) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30