Standard Name	SEC2 1, 2
Systematic Name	YNL272C
Feature Type	ORF, Verified
Description	Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles (3, 4, 5)
Name Description	SECretory 1

Chromosomal Location	ChrXIV:129084 to 126805 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -176 cM

	View Computational GO annotations for SEC2
Molecular Function
Manually curated	guanyl-nucleotide exchange factor activity (IDA) phosphatidylinositol-4-phosphate binding (IDA, IMP)
Biological Process
Manually curated	autophagy (IGI, IMP) exocytosis (IMP)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud tip (IDA) cytosol (IDA) transport vesicle (IDA)
High-throughput	mating projection tip (IDA)

Classical genetics
conditional	autophagy: decreased endomembrane system morphology: abnormal heat sensitivity: increased invertase secretion: decreased invertase accumulation: increased Ape1p (API) modification: decreased
Large-scale survey
null	inviable toxin resistance: decreased
overexpression	filamentous growth: increased
reduction of function	competitive fitness: increased
repressible	mitochondrial morphology: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	205 total interaction(s) for 124 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-RNA: 2 Affinity Capture-Western: 13 Biochemical Activity: 30 Co-crystal Structure: 2 FRET: 1 Reconstituted Complex: 15 Two-hybrid: 33
Genetic Interactions	Dosage Growth Defect: 3 Dosage Lethality: 3 Dosage Rescue: 16 Negative Genetic: 3 Positive Genetic: 1 Synthetic Growth Defect: 11 Synthetic Lethality: 47 Synthetic Rescue: 11
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:129084 to 126805 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -176 cM
Last Update	Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2280 129084..126805 2005-11-07 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005216