SEC2/YNL272C Summary Help

Standard Name SEC2 1, 2
Systematic Name YNL272C
Feature Type ORF, Verified
Description Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles (3, 4, 5)
Name Description SECretory 1
Chromosomal Location
ChrXIV:129084 to 126805 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -176 cM
Gene Ontology Annotations All SEC2 GO evidence and references
  View Computational GO annotations for SEC2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
conditional
Large-scale survey
null
overexpression
reduction of function
repressible
Resources
205 total interaction(s) for 124 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 14
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 13
  • Biochemical Activity: 30
  • Co-crystal Structure: 2
  • FRET: 1
  • Reconstituted Complex: 15
  • Two-hybrid: 33

Genetic Interactions
  • Dosage Growth Defect: 3
  • Dosage Lethality: 3
  • Dosage Rescue: 16
  • Negative Genetic: 3
  • Positive Genetic: 1
  • Synthetic Growth Defect: 11
  • Synthetic Lethality: 47
  • Synthetic Rescue: 11

Resources
Expression Summary
histogram
Resources
Length (a.a.) 759
Molecular Weight (Da) 84,651
Isoelectric Point (pI) 4.86
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:129084 to 126805 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: -176 cM
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2280 129084..126805 2005-11-07 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005216
References cited on this page View Complete Literature Guide for SEC2
1) Novick P, et al.  (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15
2) Fields, C. and Schekman, R.  (1985) Personal Communication, Mortimer Map Edition 9
3) Walch-Solimena C, et al.  (1997) Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles. J Cell Biol 137(7):1495-509
4) Medkova M, et al.  (2006) The rab exchange factor Sec2p reversibly associates with the exocyst. Mol Biol Cell 17(6):2757-69
5) Geng J, et al.  (2010) Post-golgi sec proteins are required for autophagy in Saccharomyces cerevisiae. Mol Biol Cell 21(13):2257-69