Standard Name	IST1 1
Systematic Name	YNL265C
Feature Type	ORF, Verified
Description	Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p (2, 3)
Name Description	Increased Sodium Tolerance 1

Chromosomal Location	ChrXIV:145281 to 144280 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for IST1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	late endosome to vacuole transport via multivesicular body sorting pathway (IGI)
Cellular Component
Manually curated	cytoplasm (IDA) endosome (IDA)
High-throughput	endosome (IDA)

Classical genetics
null	resistance to sirolimus: increased starvation resistance: decreased vacuolar transport: normal
Large-scale survey
null	competitive fitness: decreased resistance to acetic acid: increased resistance to L-canavanine: increased resistance to hydrogen chloride: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	42 total interaction(s) for 26 unique genes/features.
Physical Interactions	Affinity Capture-MS: 16 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Co-crystal Structure: 1 Co-localization: 4 Co-purification: 1 PCA: 3 Reconstituted Complex: 3
Genetic Interactions	Dosage Growth Defect: 2 Phenotypic Enhancement: 8 Phenotypic Suppression: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:145281 to 144280 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..27 145281..145255 2011-02-03 1996-07-31 Intron 28..132 145254..145150 2011-02-03 1996-07-31 CDS 133..1002 145149..144280 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (28 - 132)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005209