SIP3/YNL257C Summary

SIP3 BASIC INFORMATION

Standard Name	SIP3 1, 2
Systematic Name	YNL257C
Feature Type	ORF, Verified
Description	Protein that activates transcription through interaction with DNA-bound Snf1p, C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate (2, 3)
Name Description	SNF1-Interacting Protein 1

GO Annotations	All SIP3 GO evidence and references
	View Computational GO annotations for SIP3
Molecular Function
Manually curated	transcription cofactor activity (IDA)
Biological Process
Manually curated	positive regulation of transcription from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	cellular_component unknown (ND)

Regulatory Role
Regulatory modules	predicted: cellcycle ( 299 )

Mutant Phenotype	All SIP3 Phenotype details and references
Classical genetics
null	resistance to miconazole: increased
Large-scale survey
null	competitive fitness: decreased resistance to amiodarone: decreased viable

Interactions	SIP3 All interactions details and references
	5 total interaction(s) for 4 unique genes/features.
Physical Interactions	Biochemical Activity: 2 Two-hybrid: 2
Genetic Interactions	Synthetic Growth Defect: 1

Sequence Information

ChrXIV:164321 to 160632 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3690	164321..160632	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005201

SIP3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SIP3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SIP3]

1)	Yang X, et al. (1992) A protein kinase substrate identified by the two-hybrid system. Science 257(5070):680-2
2)	Lesage P, et al. (1994) Analysis of the SIP3 protein identified in a two-hybrid screen for interaction with the SNF1 protein kinase. Nucleic Acids Res 22(4):597-603
3)	Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64

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