FOL1/YNL256W Summary Help

Standard Name FOL1 1, 2
Systematic Name YNL256W
Feature Type ORF, Verified
Description Multifunctional enzyme of the folic acid biosynthesis pathway; has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities (3, 4)
Name Description FOLic acid synthesis 2
Chromosomal Location
ChrXIV:164623 to 167097 | ORF Map | GBrowse
Gbrowse
Genetic position: -170 cM
Gene Ontology Annotations All FOL1 GO evidence and references
  View Computational GO annotations for FOL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Pathways
Classical genetics
null
reduction of function
Large-scale survey
null
overexpression
reduction of function
repressible
Resources
9 total interaction(s) for 9 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • PCA: 2

Genetic Interactions
  • Dosage Lethality: 3
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 824
Molecular Weight (Da) 93,119
Isoelectric Point (pI) 6.41
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:164623 to 167097 | ORF Map | GBrowse
SGD ORF map
Genetic position: -170 cM
Last Update Coordinates: 2011-02-03 | Sequence: 2003-09-22
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2475 164623..167097 2011-02-03 2003-09-22
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005200
References cited on this page View Complete Literature Guide for FOL1
1) Game, J. and Little, J.  (1985) Personal Communication, Mortimer Map Edition 9
2) Gueldener, U., et al.  (1999) Identification and characterization of the trifunctional folic acid synthesis Fol1 protein from Saccharomyces cerevisiae.
3) Sen-Gupta M, et al.  (1997) Sequence analysis of the 33 kb long region between ORC5 and SUI1 from the left arm of chromosome XIV from Saccharomyces cerevisiae. Yeast 13(9):849-60
4) Bayly AM, et al.  (2001) Folic acid utilisation related to sulfa drug resistance in Saccharomyces cerevisiae. FEMS Microbiol Lett 204(2):387-90