Standard Name	LAP3 1
Systematic Name	YNL239W
Alias	BLH1 2 , GAL6 3 , YCP1 4
Feature Type	ORF, Verified
Description	Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH (3, 4, 5, 6, 7)
Name Description	Leucine AminoPeptidases 1

Chromosomal Location	ChrXIV:200569 to 201933 | ORF Map | GBrowse
	Genetic position: -152 cM

	View Computational GO annotations for LAP3
Molecular Function
Manually curated	cysteine-type peptidase activity (IDA) double-stranded DNA binding (IDA) mRNA binding (IDA) RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA) single-stranded DNA binding (IDA)
Biological Process
Manually curated	homocysteine catabolic process (IDA, IMP) negative regulation of transcription from RNA polymerase II promoter (IMP) response to antibiotic (IDA)
Cellular Component
Manually curated	cytoplasm (IDA)
High-throughput	cytoplasm (IDA) mitochondrion (IDA)

Classical genetics
null	metal resistance: decreased resistance to homocysteine: decreased
Large-scale survey
null	competitive fitness: increased hyperosmotic stress resistance: decreased resistance to ethanol: increased resistance to Calcofluor White: increased resistance to enzymatic treatment: increased toxin resistance: increased vacuolar morphology: abnormal viable
overexpression	filamentous growth: decreased invasive growth: absent vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	17 total interaction(s) for 16 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 7 Synthetic Growth Defect: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:200569 to 201933 | ORF Map | GBrowse
	Genetic position: -152 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 2003-01-07
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1365 200569..201933 2011-02-03 2003-01-07
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005183