Standard Name	CNM67 1
Systematic Name	YNL225C
Feature Type	ORF, Verified
Description	Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Chaotic Nuclear Migration 1

Chromosomal Location	ChrXIV:224469 to 222724 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for CNM67
Molecular Function
Manually curated	structural constituent of cytoskeleton (IPI)
Biological Process
Manually curated	microtubule nucleation (IPI) mitotic spindle organization (IMP)
Cellular Component
Manually curated	outer plaque of spindle pole body (IDA) spindle pole body (IDA)

Classical genetics
null	cellular morphology: abnormal killer toxin resistance: decreased nuclear position: abnormal resistance to Echinocandin B: decreased sporulation: absent vegetative growth: decreased
overexpression	cell cycle progression in G2 phase: abnormal nuclear morphology: abnormal
Large-scale survey
null	UV resistance: decreased anaerobic growth: decreased proton accumulation: decreased polyphosphate accumulation: abnormal glutathione excretion: increased competitive fitness: decreased fermentative growth: decreased rate heat sensitivity: increased inviable lipid particle morphology: abnormal oxidative stress resistance: decreased resistance to tunicamycin: decreased resistance to sirolimus: decreased resistance to L-1,4-dithiothreitol: decreased resistance to 1,4-dithiothreitol: decreased resistance to glycolaldehyde: decreased resistance to quinine: decreased resistance to oxalic acid: decreased sporulation: absent vegetative growth: absent vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	91 total interaction(s) for 63 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Affinity Capture-RNA: 1 Affinity Capture-Western: 4 Biochemical Activity: 4 Co-crystal Structure: 1 Co-purification: 1 FRET: 8 Reconstituted Complex: 2 Two-hybrid: 35
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 2 Dosage Rescue: 1 Negative Genetic: 1 Phenotypic Suppression: 2 Synthetic Growth Defect: 11 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 5 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:224469 to 222724 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1746 224469..222724 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005169