Standard Name	IES2
Systematic Name	YNL215W
Feature Type	ORF, Verified
Description	Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress (1, 2, 3)
Name Description	Ino Eighty Subunit 1

Chromosomal Location	ChrXIV:244468 to 245430 | ORF Map | GBrowse

	View Computational GO annotations for IES2
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	biological_process unknown (ND)
Cellular Component
High-throughput	nucleus (IDA)

Classical genetics
null	tellurium atom accumulation: increased resistance to methyl methanesulfonate: decreased resistance to hydroxyurea: decreased resistance to tellurite: increased vegetative growth: decreased viable
Large-scale survey
null	acid pH resistance: decreased auxotrophy glycogen accumulation: decreased glutathione excretion: increased competitive fitness: decreased endocytosis: decreased haploinsufficient heat sensitivity: increased oxidative stress resistance: decreased resistance to cycloheximide: increased resistance to acetic acid: increased resistance to fluconazole: increased resistance to hydroxyurea: increased resistance to methyl methanesulfonate: increased resistance to mycophenolic acid: increased resistance to oleate: decreased resistance to arsenite(3-): decreased resistance to tunicamycin: decreased resistance to bleomycin: decreased resistance to fenpropimorph: decreased resistance to boric acid: decreased resistance to caffeine: increased resistance to L-1,4-dithiothreitol: decreased resistance to 1,4-dithiothreitol: decreased resistance to benzo[a]pyrene: decreased resistance to Azaserine: decreased resistance to cycloheximide: decreased resistance to hydroxyurea: decreased resistance to quercetin: decreased resistance to isopropyl (N-3-chloro-phenyl)-carbamate: decreased stress resistance: increased toxin resistance: increased vacuolar morphology: abnormal vegetative growth: decreased vegetative growth: decreased rate vegetative growth: absent viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	295 total interaction(s) for 235 unique genes/features.
Physical Interactions	Affinity Capture-MS: 26 Affinity Capture-RNA: 2 Biochemical Activity: 1
Genetic Interactions	Negative Genetic: 204 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 24 Synthetic Growth Defect: 29 Synthetic Lethality: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:244468 to 245430 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..963 244468..245430 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005159