RTT106/YNL206C Summary Help

Standard Name RTT106 1
Systematic Name YNL206C
Feature Type ORF, Verified
Description Histone chaperone; involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition; interacts physically and functionally with Chromatin Assembly Factor-1 (CAF-1) (1, 2, 3, 4)
Name Description Regulator of Ty1 Transposition 1
Chromosomal Location
ChrXIV:258155 to 256788 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RTT106 GO evidence and references
  View Computational GO annotations for RTT106
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
221 total interaction(s) for 139 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 34
  • Biochemical Activity: 1
  • Co-localization: 3
  • Reconstituted Complex: 22
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Growth Defect: 4
  • Negative Genetic: 43
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 1
  • Positive Genetic: 13
  • Synthetic Growth Defect: 22
  • Synthetic Lethality: 55
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 455
Molecular Weight (Da) 51,621
Isoelectric Point (pI) 4.24
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:258155 to 256788 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1368 258155..256788 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005150
References cited on this page View Complete Literature Guide for RTT106
1) Scholes DT, et al.  (2001) Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance. Genetics 159(4):1449-65
2) Huang S, et al.  (2005) Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing. Proc Natl Acad Sci U S A 102(38):13410-5
3) Imbeault D, et al.  (2008) The rtt106 histone chaperone is functionally linked to transcription elongation and is involved in the regulation of spurious transcription from cryptic promoters in yeast. J Biol Chem 283(41):27350-4
4) Fillingham J, et al.  (2009) Two-color cell array screen reveals interdependent roles for histone chaperones and a chromatin boundary regulator in histone gene repression. Mol Cell 35(3):340-51