Standard Name	RTT106 1
Systematic Name	YNL206C
Feature Type	ORF, Verified
Description	Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition (1, 2, 3, 4)
Name Description	Regulator of Ty1 Transposition 1

Chromosomal Location	ChrXIV:258155 to 256788 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RTT106
Molecular Function
Manually curated	double-stranded DNA binding (IDA, IMP) histone binding (IDA, IMP, IPI)
Biological Process
Manually curated	DNA replication-dependent nucleosome assembly (IGI) DNA replication-independent nucleosome assembly (IMP) heterochromatin assembly involved in chromatin silencing (IGI, IMP) negative regulation of transcription from RNA polymerase II promoter (IMP) transcription elongation from RNA polymerase II promoter (IGI, IMP)
Cellular Component
High-throughput	nucleus (IDA)

Classical genetics
null	resistance to camptothecin: decreased silencing: decreased transposable element transposition: increased rate
Large-scale survey
null	acid pH resistance: decreased anaerobic growth: decreased bud morphology: abnormal competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased hyperosmotic stress resistance: decreased Hta1p-GFP accumulation: increased resistance to methyl methanesulfonate: increased resistance to hydroxyurea: increased resistance to fluconazole: increased resistance to caffeine: increased resistance to sanguinarine: decreased resistance to ruthenium red: decreased resistance to zinc chloride: decreased resistance to cycloheximide: decreased resistance to cesium chloride: decreased resistance to Azaserine: decreased resistance to benzamidine: decreased resistance to isopropyl (N-3-chloro-phenyl)-carbamate: decreased resistance to caffeine: decreased resistance to Loperamide: decreased resistance to mycophenolic acid: increased resistance to tunicamycin: increased resistance to doxorubicin: decreased resistance to quinine: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to bleomycin: decreased resistance to trisodium vanadate: increased resistance to thiabendazole: decreased stress resistance: decreased transposable element transposition: increased vegetative growth: decreased vegetative growth: decreased rate viable
overexpression	resistance to sirolimus: increased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	221 total interaction(s) for 139 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-RNA: 2 Affinity Capture-Western: 34 Biochemical Activity: 1 Co-localization: 3 Reconstituted Complex: 22 Two-hybrid: 6
Genetic Interactions	Dosage Growth Defect: 5 Negative Genetic: 43 Phenotypic Enhancement: 3 Phenotypic Suppression: 1 Positive Genetic: 12 Synthetic Growth Defect: 22 Synthetic Lethality: 55 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:258155 to 256788 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1368 258155..256788 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005150