PSD1/YNL169C Summary Help

Standard Name PSD1 1
Systematic Name YNL169C
Feature Type ORF, Verified
Description Phosphatidylserine decarboxylase of the mitochondrial inner membrane; converts phosphatidylserine to phosphatidylethanolamine; regulates mitochondrial fusion and morphology by affecting lipid mixing in the mitochondrial membrane and by influencing the ratio of long to short forms of Mgm1p; partly exposed to the mitochondrial intermembrane space (2, 3, 4, 5)
Name Description PhosphatidylSerine Decarboxylase 1
Chromosomal Location
ChrXIV:317671 to 316169 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PSD1 GO evidence and references
  View Computational GO annotations for PSD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 9 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
overexpression
Resources
564 total interaction(s) for 391 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-Western: 4
  • PCA: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 6
  • Negative Genetic: 403
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 2
  • Positive Genetic: 80
  • Synthetic Growth Defect: 35
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 22

Resources
Expression Summary
histogram
Resources
Length (a.a.) 500
Molecular Weight (Da) 56,594
Isoelectric Point (pI) 9.84
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:317671 to 316169 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1503 317671..316169 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005113
References cited on this page View Complete Literature Guide for PSD1
1) Clancey CJ, et al.  (1993) Cloning of a gene (PSD1) encoding phosphatidylserine decarboxylase from Saccharomyces cerevisiae by complementation of an Escherichia coli mutant. J Biol Chem 268(33):24580-90
2) Carson MA, et al.  (1984) Coordinate regulation of phosphatidylserine decarboxylase activity and phospholipid N-methylation in yeast. J Biol Chem 259(10):6267-73
3) Voelker DR  (1997) Phosphatidylserine decarboxylase. Biochim Biophys Acta 1348(1-2):236-44
4) Storey MK, et al.  (2001) Phosphatidylethanolamine has an essential role in Saccharomyces cerevisiae that is independent of its ability to form hexagonal phase structures. J Biol Chem 276(51):48539-48
5) Chan EY and McQuibban GA  (2012) Phosphatidylserine decarboxylase 1 (Psd1) promotes mitochondrial fusion by regulating the biophysical properties of the mitochondrial membrane and alternative topogenesis of mitochondrial genome maintenance protein 1 (Mgm1). J Biol Chem 287(48):40131-9