CUZ1/YNL155W Summary Help

Standard Name CUZ1 1
Systematic Name YNL155W
Feature Type ORF, Verified
Description Protein with a role in the ubiquitin-proteasome pathway; interacts with ubiquitinated protein, Cdc48p and the proteasomal regulatory particle; may protect cells from trivalent metalloid induced proteotoxicity; contains a PACE promoter element and is co-regulated with proteasome subunit genes; AN1-type zinc finger protein, with DHHC and ubiquitin-like domains (UBL); ortholog of ZFAND1, a human gene linked to cancer; protein abundance increases under DNA replication stress (1, 2, 3, 4, 5)
Name Description Cdc48-associated UBL/Zn-finger protein 1
Chromosomal Location
ChrXIV:342516 to 343340 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CUZ1 GO evidence and references
  View Computational GO annotations for CUZ1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 9 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
75 total interaction(s) for 63 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 35
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 4
  • Biochemical Activity: 7
  • Reconstituted Complex: 6
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 13
  • Positive Genetic: 1
  • Synthetic Growth Defect: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 274
Molecular Weight (Da) 31,516
Isoelectric Point (pI) 9.47
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:342516 to 343340 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..825 342516..343340 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005099
References cited on this page View Complete Literature Guide for CUZ1
1) Sa-Moura B, et al.  (2013) A Conserved Protein with AN1 Zinc Finger and Ubiquitin-like Domains Modulates Cdc48 (p97) Function in the Ubiquitin-Proteasome Pathway. J Biol Chem 288(47):33682-96
2) Mitchell DA, et al.  (2006) Protein palmitoylation by a family of DHHC protein S-acyltransferases. J Lipid Res 47(6):1118-27
3) Brohee S, et al.  (2011) Unraveling networks of co-regulated genes on the sole basis of genome sequences. Nucleic Acids Res 39(15):6340-58
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5) Hanna J, et al.  (2014) Cuz1/Ynl155w, a Zinc-dependent Ubiquitin-binding Protein, Protects Cells from Metalloid-induced Proteotoxicity. J Biol Chem 289(3):1876-85