Standard Name	FYV6
Systematic Name	YNL133C
Feature Type	ORF, Verified
Description	Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining (1, 2)
Name Description	Function required for Yeast Viability 1

Chromosomal Location	ChrXIV:374692 to 374171 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for FYV6
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	double-strand break repair via nonhomologous end joining (IMP)
Cellular Component
High-throughput	nucleus (IDA)

Classical genetics
null	resistance to FK506: decreased
Large-scale survey
null	alkaline pH resistance: decreased auxotrophy proton accumulation: increased glycogen accumulation: increased competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate haploproficient heat sensitivity: increased Can1p-GFP distribution: abnormal resistance to hydroxyurea: increased resistance to farnesol: decreased resistance to miconazole: decreased resistance to methanol: decreased resistance to ethanol: decreased resistance to hydroxyurea: decreased resistance to benomyl: decreased resistance to caffeine: decreased resistance to sulfometuron methyl: decreased resistance to hydrogen chloride: decreased resistance to quinine: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to sulfanilamide: decreased resistance to L-1,4-dithiothreitol: decreased resistance to calcium dichloride: decreased resistance to sorbate: decreased respiratory growth: decreased rate telomere length: increased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	filamentous growth: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	11 total interaction(s) for 11 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1 Biochemical Activity: 2
Genetic Interactions	Dosage Growth Defect: 1 Phenotypic Enhancement: 1 Positive Genetic: 1 Synthetic Growth Defect: 1 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:374692 to 374171 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..522 374692..374171 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005077