| Standard Name | TEP1 |
|---|---|
| Systematic Name | YNL128W |
| Feature Type | ORF, Verified |
| Description | PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1 (1, 2, 3, 4) |
| Name Description | TEnsin-like Phosphatase 1 |
| Chromosomal Location | |
|---|---|
Gene Ontology Annotations All TEP1 GO evidence and references
| View Computational GO annotations for TEP1 | |
| Molecular Function | |
| Manually curated |
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| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated |
Mutant phenotypes All TEP1 Phenotype evidence and references
| Classical genetics | |
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| null |
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| Large-scale survey | |
| null |
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| Resources |
interactions All TEP1 Interaction evidence and references
| 40 total interaction(s) for 37 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All TEP1 Protein evidence and references
| Localization | |
|---|---|
| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
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| Last Update | Coordinates: 2011-02-03 | Sequence: 2011-02-03 | ||||||||||||
| Subfeature details |
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| Retrieve sequences | |||||||||||||
Analyze Sequence
| S288C only | |
|---|---|
| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000005072 |
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References cited on this page View Complete Literature Guide for TEP1
| 1) | Heymont J, et al. (2000) TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation. Proc Natl Acad Sci U S A 97(23):12672-7 |
| 2) | Mitra P, et al. (2004) A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. J Cell Biol 166(2):205-11 |
| 3) | Rodriguez-Escudero I, et al. (2005) Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast. Biochem J 390(Pt 2):613-23 |
| 4) | Maehama T, et al. (2001) PTEN and myotubularin: novel phosphoinositide phosphatases. Annu Rev Biochem 70():247-79 |




