Standard Name	DCP2
Systematic Name	YNL118C
Alias	PSU1
Feature Type	ORF, Verified
Description	Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex; removes the 5' cap structure from mRNAs prior to their degradation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress (1, 2, 3, 4, 5)
Name Description	mRNA DeCaPping 6

Chromosomal Location	ChrXIV:405564 to 402652 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for DCP2
Molecular Function
Manually curated	hydrolase activity (IDA) m7G(5')pppN diphosphatase activity (IDA) mRNA binding (IPI)
Biological Process
Manually curated	deadenylation-dependent decapping of nuclear-transcribed mRNA (IDA, IMP) deadenylation-independent decapping of nuclear-transcribed mRNA (IMP) stress granule assembly (IGI, IMP)
Cellular Component
Manually curated	cytoplasmic mRNA processing body (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	apoptosis: increased
unspecified	ribosomal protein mRNA accumulation: increased
Large-scale survey
conditional	colony sectoring: increased
null	competitive fitness: decreased haploinsufficient inviable starvation resistance: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	196 total interaction(s) for 140 unique genes/features.
Physical Interactions	Affinity Capture-MS: 30 Affinity Capture-RNA: 5 Affinity Capture-Western: 8 Biochemical Activity: 2 Co-purification: 1 PCA: 12 Reconstituted Complex: 9 Two-hybrid: 43
Genetic Interactions	Dosage Rescue: 4 Negative Genetic: 66 Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Positive Genetic: 7 Synthetic Growth Defect: 2 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:405564 to 402652 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2913 405564..402652 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005062