Standard Name	DBP2
Systematic Name	YNL112W
Feature Type	ORF, Verified
Description	ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites (1, 2)
Name Description	Dead Box Protein

Chromosomal Location	ChrXIV:413639 to 416281 | ORF Map | GBrowse

	View Computational GO annotations for DBP2
Molecular Function
Manually curated	RNA helicase activity (ISS) RNA-dependent ATPase activity (IDA, IMP)
Biological Process
Manually curated	nuclear polyadenylation-dependent mRNA catabolic process (IGI, IMP) nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (IPI) rRNA processing (IMP)
Cellular Component
Manually curated	nucleus (IDA)
High-throughput	cytoplasm (IDA) mitochondrion (IDA) nucleus (IDA)

Classical genetics
null	GAL7 mRNA accumulation: increased cold sensitivity: increased vegetative growth: decreased viable
Large-scale survey
null	inviable toxin resistance: decreased
reduction of function	competitive fitness: decreased resistance to methyl methanesulfonate: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	96 total interaction(s) for 82 unique genes/features.
Physical Interactions	Affinity Capture-MS: 61 Affinity Capture-RNA: 4 Biochemical Activity: 1 PCA: 17 Reconstituted Complex: 1 Two-hybrid: 4
Genetic Interactions	Negative Genetic: 1 Positive Genetic: 4 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:413639 to 416281 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1273 413639..414911 2011-02-03 1996-07-31 Intron 1274..2275 414912..415913 2011-02-03 1996-07-31 CDS 2276..2643 415914..416281 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (1274 - 2275)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005056