MIC27/YNL100W Summary Help

Standard Name MIC27 1
Systematic Name YNL100W
Alias MCS27 2 , AIM37 3
Feature Type ORF, Verified
Description Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (2, 4, 5)
Name Description MItochondrial contact site and Cristae organizing system 1
Chromosomal Location
ChrXIV:437613 to 438317 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MIC27 GO evidence and references
  View Computational GO annotations for MIC27
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
46 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 12
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 14
  • Co-purification: 3

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 12
  • Positive Genetic: 2
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 234
Molecular Weight (Da) 26,960
Isoelectric Point (pI) 10.18
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:437613 to 438317 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..705 437613..438317 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005044
References cited on this page View Complete Literature Guide for MIC27
1) Pfanner N, et al.  (2014) Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol 204(7):1083-6
2) Harner M, et al.  (2011) The mitochondrial contact site complex, a determinant of mitochondrial architecture.LID - 10.1038/emboj.2011.379 [doi] EMBO J ()
3) Hess DC, et al.  (2009) Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet 5(3):e1000407
4) von der Malsburg K, et al.  (2011) Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. Dev Cell 21(4):694-707
5) Hoppins S, et al.  (2011) A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol 195(2):323-40