Standard Name	NOP2
Systematic Name	YNL061W
Alias	YNA1
Feature Type	ORF, Verified
Description	Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles (1, 2, 3, 4)
Name Description	NucleOlar Protein 1

Chromosomal Location	ChrXIV:510540 to 512396 | ORF Map | GBrowse

	View Computational GO annotations for NOP2
Molecular Function
Manually curated	RNA methyltransferase activity (TAS) S-adenosylmethionine-dependent methyltransferase activity (ISS)
Biological Process
Manually curated	rRNA processing (TAS)
Cellular Component
Manually curated	nucleolus (TAS)
High-throughput	preribosome, large subunit precursor (IDA)

Large-scale survey
null	cell size: decreased competitive fitness: decreased haploinsufficient inviable
overexpression	cell cycle progression: abnormal
reduction of function	competitive fitness: decreased
repressible	mitochondrial morphology: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	247 total interaction(s) for 131 unique genes/features.
Physical Interactions	Affinity Capture-MS: 201 Affinity Capture-RNA: 3 Affinity Capture-Western: 4 Two-hybrid: 6
Genetic Interactions	Negative Genetic: 22 Positive Genetic: 1 Synthetic Growth Defect: 3 Synthetic Lethality: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:510540 to 512396 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1857 510540..512396 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005005