LAP2/YNL045W Summary Help

Standard Name LAP2 1, 2
Systematic Name YNL045W
Feature Type ORF, Verified
Description Leucyl aminopeptidase yscIV with epoxide hydrolase activity; metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; also known as leukotriene A4 hydrolase (3, 4, 5, 6)
Name Description Leucine AminoPeptidases 1
Chromosomal Location
ChrXIV:542963 to 544978 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All LAP2 GO evidence and references
  View Computational GO annotations for LAP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 2 genes
Resources
Large-scale survey
null
Resources
29 total interaction(s) for 26 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 12
  • Affinity Capture-RNA: 3
  • Biochemical Activity: 5
  • Co-purification: 1
  • PCA: 1
  • Protein-peptide: 3

Genetic Interactions
  • Negative Genetic: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 671
Molecular Weight (Da) 77,352
Isoelectric Point (pI) 6.56
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:542963 to 544978 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2016 542963..544978 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004990
References cited on this page View Complete Literature Guide for LAP2
1) Trumbly RJ and Bradley G  (1983) Isolation and characterization of aminopeptidase mutants of Saccharomyces cerevisiae. J Bacteriol 156(1):36-48
2) Schu P  (2008) Aminopeptidase I enzymatic activity. Methods Enzymol 451:67-78
3) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
4) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
5) Kull F, et al.  (2001) Saccharomyces cerevisiae leukotriene A4 hydrolase: formation of leukotriene B4 and identification of catalytic residues. Biochemistry 40(42):12695-703
6) Andersson B, et al.  (2003) Crystallization and X-ray diffraction data analysis of leukotriene A4 hydrolase from Saccharomyces cerevisiae. Acta Crystallogr D Biol Crystallogr 59(Pt 6):1093-5