YND1/YER005W Summary Help

Standard Name YND1 1
Systematic Name YER005W
Alias APY1 2 , YEJ5
Feature Type ORF, Verified
Description Apyrase with wide substrate specificity; helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity (1, 3)
Name Description Yeast Nucleoside Diphosphatase 1
Chromosomal Location
ChrV:160550 to 162442 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YND1 GO evidence and references
  View Computational GO annotations for YND1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 103 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
82 total interaction(s) for 62 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • PCA: 10
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Negative Genetic: 53
  • Phenotypic Enhancement: 1
  • Positive Genetic: 3
  • Synthetic Growth Defect: 3
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 630
Molecular Weight (Da) 71,851
Isoelectric Point (pI) 6.19
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:160550 to 162442 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1893 160550..162442 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000807
References cited on this page View Complete Literature Guide for YND1
1) Gao XD, et al.  (1999) YND1, a homologue of GDA1, encodes membrane-bound apyrase required for Golgi N- and O-glycosylation in Saccharomyces cerevisiae. J Biol Chem 274(30):21450-6
2) Zhong X and Guidotti G  (1999) A yeast Golgi E-type ATPase with an unusual membrane topology. J Biol Chem 274(46):32704-11
3) Mittelman K, et al.  (2010) The Cytosolic Tail of the Golgi Apyrase Ynd1 Mediates E4orf4-Induced Toxicity in Saccharomyces cerevisiae. PLoS One 5(11):e15539