Standard Name	TMA23 1
Systematic Name	YMR269W
Alias	YMR268W-A
Feature Type	ORF, Verified
Description	Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan (1, 2, 3)
Name Description	Translation Machinery Associated 2

Chromosomal Location	ChrXIII:804456 to 805091 | ORF Map | GBrowse

	View Computational GO annotations for TMA23
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ribosomal small subunit biogenesis (IGI)
Cellular Component
Manually curated	nucleolus (IDA)
High-throughput	nucleolus (IDA) colocalizes_with ribosome (IDA)

Classical genetics
null	chronological lifespan: increased resistance to cycloheximide: decreased
Large-scale survey
null	cell cycle progression in G1 phase: increased duration cell size: decreased competitive fitness: decreased fermentative growth: decreased rate haploinsufficient heat sensitivity: increased Fus-Mid-GFP distribution: abnormal resistance to sirolimus: increased resistance to mycophenolic acid: increased resistance to methyl methanesulfonate: increased resistance to cycloheximide: increased resistance to bleomycin: increased resistance to formaldehyde: decreased resistance to tunicamycin: increased resistance to 5-fluorouracil: decreased resistance to camptothecin: increased resistance to doxorubicin: decreased starvation resistance: decreased toxin resistance: increased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	133 total interaction(s) for 102 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 2 PCA: 5 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 88 Phenotypic Enhancement: 1 Phenotypic Suppression: 3 Positive Genetic: 22 Synthetic Growth Defect: 7 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:804456 to 805091 | ORF Map | GBrowse
	This feature contains embedded feature(s): YMR268W-A
Last Update	Coordinates: 2011-02-03 | Sequence: 2004-02-27
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..636 804456..805091 2011-02-03 2004-02-27
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004882