GFD1/YMR255W Summary Help

Standard Name GFD1 1
Systematic Name YMR255W
Feature Type ORF, Verified
Description Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress (1, 2)
Name Description Good For Dbp5p 1
Chromosomal Location
ChrXIII:778001 to 778567 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GFD1 GO evidence and references
  View Computational GO annotations for GFD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Large-scale survey
null
Resources
60 total interaction(s) for 34 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 1
  • Co-crystal Structure: 1
  • PCA: 1
  • Reconstituted Complex: 8
  • Two-hybrid: 12

Genetic Interactions
  • Dosage Rescue: 5
  • Negative Genetic: 10
  • Positive Genetic: 9
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 188
Molecular Weight (Da) 21,571
Isoelectric Point (pI) 10.54
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:778001 to 778567 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..567 778001..778567 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004868
References cited on this page View Complete Literature Guide for GFD1
1) Hodge CA, et al.  (1999) Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells. EMBO J 18(20):5778-88
2) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76