CUS1/YMR240C Summary Help

Standard Name CUS1 1
Systematic Name YMR240C
Feature Type ORF, Verified
Description Protein required for assembly of U2 snRNP into the spliceosome; forms a complex with Hsh49p and Hsh155p (2)
Name Description Cold sensitive U2 snRNA Suppressor 1
Chromosomal Location
ChrXIII:751240 to 749930 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All CUS1 GO evidence and references
  View Computational GO annotations for CUS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Large-scale survey
null
overexpression
reduction of function
Resources
129 total interaction(s) for 63 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 97
  • Affinity Capture-Western: 3
  • Co-purification: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 14

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 2
  • Positive Genetic: 4
  • Synthetic Lethality: 4
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 436
Molecular Weight (Da) 50,253
Isoelectric Point (pI) 9.01
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:751240 to 749930 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1311 751240..749930 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004853
References cited on this page View Complete Literature Guide for CUS1
1) Wells SE, et al.  (1996) CUS1, a suppressor of cold-sensitive U2 snRNA mutations, is a novel yeast splicing factor homologous to human SAP 145. Genes Dev 10(2):220-32
2) Pauling MH, et al.  (2000) Functional Cus1p is found with Hsh155p in a multiprotein splicing factor associated with U2 snRNA. Mol Cell Biol 20(6):2176-85