VTI1/YMR197C Summary Help

Standard Name VTI1 1
Systematic Name YMR197C
Feature Type ORF, Verified
Description Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways (1, 2, 3)
Name Description Vps10 (Ten) Interacting 1
Chromosomal Location
ChrXIII:659198 to 658545 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All VTI1 GO evidence and references
  View Computational GO annotations for VTI1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 88 genes
Resources
Classical genetics
conditional
null
repressible
Large-scale survey
conditional
null
overexpression
reduction of function
Resources
162 total interaction(s) for 64 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 58
  • Co-crystal Structure: 1
  • Co-fractionation: 4
  • Co-localization: 2
  • Co-purification: 9
  • Reconstituted Complex: 26
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 1
  • Dosage Rescue: 12
  • Negative Genetic: 22
  • Phenotypic Enhancement: 2
  • Positive Genetic: 4
  • Synthetic Lethality: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 217
Molecular Weight (Da) 24,668
Isoelectric Point (pI) 6.58
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:659198 to 658545 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..654 659198..658545 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004810
References cited on this page View Complete Literature Guide for VTI1
1) von Mollard GF, et al.  (1997) The yeast v-SNARE Vti1p mediates two vesicle transport pathways through interactions with the t-SNAREs Sed5p and Pep12p. J Cell Biol 137(7):1511-24
2) Lupashin VV, et al.  (1997) Characterization of a novel yeast SNARE protein implicated in Golgi retrograde traffic. Mol Biol Cell 8(12):2659-76
3) Fischer von Mollard G and Stevens TH  (1999) The Saccharomyces cerevisiae v-SNARE Vti1p is required for multiple membrane transport pathways to the vacuole. Mol Biol Cell 10(6):1719-32