Standard Name	CEP3 1
Systematic Name	YMR168C
Alias	CBF3 2 , CSL1 3
Feature Type	ORF, Verified
Description	Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain (1, 4, 5) Also known as: CBF3B 2
Name Description	CEntromere Protein 6

Chromosomal Location	ChrXIII:599158 to 597332 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for CEP3
Molecular Function
Manually curated	centromeric DNA binding (IDA) DNA binding, bending (IDA)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	mitotic spindle assembly checkpoint (IMP) septin ring assembly (IMP)
Cellular Component
Manually curated	CBF3 complex (IDA) condensed nuclear chromosome kinetochore (IDA)

Binding motifs	TCSGAA 7 [Search intergenic regions for TCSGAA] YTCGGAA 8 [Search intergenic regions for YTCGGAA]
Resources	ScerTF | UniProbe | YeTFaSCo

Classical genetics
null	bud neck morphology: abnormal cytokinesis: abnormal viable
Large-scale survey
conditional	colony sectoring: increased
null	inviable
overexpression	vegetative growth: decreased rate
reduction of function	competitive fitness: decreased
repressible	mitochondrial morphology: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	93 total interaction(s) for 75 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Co-crystal Structure: 2 Co-purification: 1 Reconstituted Complex: 8 Two-hybrid: 24
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 1 Phenotypic Enhancement: 1 Positive Genetic: 1 Synthetic Growth Defect: 31 Synthetic Lethality: 13
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:599158 to 597332 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1827 599158..597332 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004778