NDE1/YMR145C Summary Help

NDE1 BASIC INFORMATION

Standard Name NDE1 1
Systematic Name YMR145C
Alias NDH1
Feature Type ORF, Verified
Description Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain (1, 2, 3, 4, 5)
Name Description NADH Dehydrogenase, External 1
GO Annotations All NDE1 GO evidence and references
    View Computational GO annotations for NDE1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All NDE1 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Interactions NDE1 All interactions details and references
  View additional details at BioGRID
21 total interaction(s) for 16 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
Genetic Interactions
  • Negative Genetic: 12
  • Phenotypic Enhancement: 2
  • Synthetic Growth Defect: 2
Sequence Information
ChrXIII:556474 to 554792 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1683 556474..554792 1996-07-31 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004753

NDE1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for NDE1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NDE1]

1) Luttik MA, et al.  (1998) The Saccharomyces cerevisiae NDE1 and NDE2 genes encode separate mitochondrial NADH dehydrogenases catalyzing the oxidation of cytosolic NADH. J Biol Chem 273(38):24529-34
2) Overkamp KM, et al.  (2000) In vivo analysis of the mechanisms for oxidation of cytosolic NADH by Saccharomyces cerevisiae mitochondria. J Bacteriol 182(10):2823-30
3) Small WC and McAlister-Henn L  (1998) Identification of a cytosolically directed NADH dehydrogenase in mitochondria of Saccharomyces cerevisiae. J Bacteriol 180(16):4051-5
4) Pahlman IL, et al.  (2002) Kinetic regulation of the mitochondrial glycerol-3-phosphate dehydrogenase by the external NADH dehydrogenase in Saccharomyces cerevisiae. J Biol Chem 277(31):27991-5
5) Melo AM, et al.  (2004) New insights into type II NAD(P)H:quinone oxidoreductases. Microbiol Mol Biol Rev 68(4):603-16