EPO1/YMR124W Summary Help

Standard Name EPO1 1
Systematic Name YMR124W
Feature Type ORF, Verified
Description Protein involved in septin-ER tethering; interacts with ER membrane protein, Scs2p, and Shs1p, a septin ring component, at bud neck to create ER diffusion barrier; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W has a paralog, YLR031W, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6)
Name Description Endoplasmic reticulum POlarization 1
Chromosomal Location
ChrXIII:514456 to 517287 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All EPO1 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Large-scale survey
null
Resources
39 total interaction(s) for 35 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 2
  • Two-hybrid: 20

Genetic Interactions
  • Negative Genetic: 10
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 943
Molecular Weight (Da) 105,913
Isoelectric Point (pI) 6.88
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:514456 to 517287 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2832 514456..517287 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004731
References cited on this page View Complete Literature Guide for EPO1
1) Chao JT, et al.  (2014) Polarization of the Endoplasmic Reticulum by ER-Septin Tethering. Cell 158(3):620-632
2) Jensen TH, et al.  (2000) Identification of novel Saccharomyces cerevisiae proteins with nuclear export activity: cell cycle-regulated transcription factor ace2p shows cell cycle-independent nucleocytoplasmic shuttling. Mol Cell Biol 20(21):8047-58
3) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
4) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Roy S, et al.  (2009) Exploiting amino acid composition for predicting protein-protein interactions. PLoS One 4(11):e7813