Standard Name	ADE17 1
Systematic Name	YMR120C
Feature Type	ORF, Verified
Description	Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine (2, 3)
Name Description	ADEnine 1

Chromosomal Location	ChrXIII:509280 to 507502 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for ADE17
Molecular Function
Manually curated	IMP cyclohydrolase activity (IDA) phosphoribosylaminoimidazolecarboxamide formyltransferase activity (IDA)
Biological Process
Manually curated	'de novo' IMP biosynthetic process (IDA, IMP) purine nucleotide biosynthetic process (IDA, IMP)
Cellular Component
Manually curated	cytosol (IDA)
High-throughput	plasma membrane (IDA)

Pathways	de novo biosynthesis of purine nucleotides superpathway of histidine, purine, and pyrimidine biosynthesis superpathway of purine biosynthesis and salvage pathways

Classical genetics
null	chromosome/plasmid maintenance: abnormal resistance to cisplatin: increased
Large-scale survey
null	competitive fitness: decreased haploinsufficient resistance to methyl methanesulfonate: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	82 total interaction(s) for 60 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-RNA: 1 Biochemical Activity: 3 PCA: 27 Protein-peptide: 3 Reconstituted Complex: 3
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 20 Positive Genetic: 4 Synthetic Growth Defect: 2 Synthetic Lethality: 2 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:509280 to 507502 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1779 509280..507502 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004727