ASI1/YMR119W Summary Help

Standard Name ASI1 1
Systematic Name YMR119W
Feature Type ORF, Verified
Description Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication (1, 2, 3)
Name Description Amino acid Sensor-Independent 1
Chromosomal Location
ChrXIII:505333 to 507207 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ASI1 GO evidence and references
  View Computational GO annotations for ASI1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Large-scale survey
null
overexpression
Resources
32 total interaction(s) for 27 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1

Genetic Interactions
  • Negative Genetic: 20
  • Phenotypic Enhancement: 1
  • Positive Genetic: 2
  • Synthetic Growth Defect: 2
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 624
Molecular Weight (Da) 71,443
Isoelectric Point (pI) 5.66
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:505333 to 507207 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1875 505333..507207 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004725
References cited on this page View Complete Literature Guide for ASI1
1) Forsberg H, et al.  (2001) Suppressors of ssy1 and ptr3 null mutations define novel amino acid sensor-independent genes in Saccharomyces cerevisiae. Genetics 158(3):973-88
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Zargari A, et al.  (2007) Inner nuclear membrane proteins asi1, asi2, and asi3 function in concert to maintain the latent properties of transcription factors stp1 and stp2. J Biol Chem 282(1):594-605