Standard Name	CTF18
Systematic Name	YMR078C
Alias	CHL12 1
Feature Type	ORF, Verified
Description	Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint (2, 3)
Name Description	Chromosome Transmission Fidelity 4

Chromosomal Location	ChrXIII:424728 to 422503 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for CTF18
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	DNA replication initiation (IMP) double-strand break repair via homologous recombination (IMP) maintenance of DNA trinucleotide repeats (IMP) mitotic sister chromatid cohesion (IGI, IMP)
Cellular Component
Manually curated	Ctf18 RFC-like complex (IPI) nuclear replication fork (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	chromosome segregation: premature chromosome segregation: abnormal chromosome/plasmid maintenance: abnormal colony sectoring: increased GFP-Rap1 distribution: abnormal Smc3p modification: decreased resistance to benomyl: decreased resistance to methyl methanesulfonate: decreased resistance to hydroxyurea: decreased resistance to phleomycin: decreased resistance to camptothecin: decreased resistance to bleomycin A2: decreased telomere length: decreased
Large-scale survey
null	anaerobic growth: decreased cell cycle progression in G1 phase: increased duration glycogen accumulation: increased competitive fitness: decreased haploinsufficient heat sensitivity: increased resistance to quinine: decreased resistance to CTBT: decreased resistance to methyl methanesulfonate: decreased resistance to amiodarone: decreased resistance to mycophenolic acid: increased resistance to fenpropimorph: increased resistance to caffeine: increased resistance to cycloheximide: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to bleomycin: decreased resistance to camptothecin: decreased resistance to hydroxyurea: decreased resistance to sirolimus: decreased resistance to sodium selenide: decreased resistance to cisplatin: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	783 total interaction(s) for 353 unique genes/features.
Physical Interactions	Affinity Capture-MS: 23 Affinity Capture-Western: 18 Co-purification: 5 Reconstituted Complex: 8
Genetic Interactions	Dosage Growth Defect: 12 Dosage Lethality: 7 Negative Genetic: 300 Phenotypic Enhancement: 22 Phenotypic Suppression: 6 Positive Genetic: 21 Synthetic Growth Defect: 236 Synthetic Lethality: 123 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:424728 to 422503 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2226 424728..422503 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004683