MCM1/YMR043W Summary Help

Standard Name MCM1 1, 2, 3
Systematic Name YMR043W
Alias FUN80 4
Feature Type ORF, Verified
Description Transcription factor; involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes; relocalizes to the cytosol in response to hypoxia (5, 6, 7, 8)
Name Description MiniChromosome Maintenance 9
Chromosomal Location
ChrXIII:353871 to 354731 | ORF Map | GBrowse
Gbrowse
Genetic position: 35 cM
Gene Ontology Annotations All MCM1 GO evidence and references
  View Computational GO annotations for MCM1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 58 genes
Regulators 2 genes
Resources
Classical genetics
conditional
overexpression
reduction of function
repressible
Large-scale survey
conditional
null
overexpression
reduction of function
Resources
65 total interaction(s) for 39 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 8
  • Co-crystal Structure: 2
  • PCA: 1
  • Reconstituted Complex: 14
  • Two-hybrid: 11

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 8
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 6
  • Synthetic Lethality: 3
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 286
Molecular Weight (Da) 32,802
Isoelectric Point (pI) 4.86
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:353871 to 354731 | ORF Map | GBrowse
SGD ORF map
Genetic position: 35 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..861 353871..354731 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004646
References cited on this page View Complete Literature Guide for MCM1
1) Maine, G.T.  (1984) Ph.D. thesis Personal Communication
2) Maine, G. and Tye, B.  (1985) Personal Communication, Mortimer Map Edition 9
3) Elble, R., et al.  (1989) ; Personal Communication, Mortimer Map Edition 10
4) Dubois E, et al.  (1987) Characterization of two new genes essential for vegetative growth in Saccharomyces cerevisiae: nucleotide sequence determination and chromosome mapping. Gene 55(2-3):265-75
5) Passmore S, et al.  (1989) A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes. Genes Dev 3(7):921-35
6) Elble R and Tye BK  (1991) Both activation and repression of a-mating-type-specific genes in yeast require transcription factor Mcm1. Proc Natl Acad Sci U S A 88(23):10966-70
7) Lydall D, et al.  (1991) A new role for MCM1 in yeast: cell cycle regulation of SW15 transcription. Genes Dev 5(12B):2405-19
8) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30
9) Maine GT, et al.  (1984) Mutants of S. cerevisiae defective in the maintenance of minichromosomes. Genetics 106(3):365-85
10) Harbison CT, et al.  (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431(7004):99-104
11) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66
12) Matys V, et al.  (2003) TRANSFAC: transcriptional regulation, from patterns to profiles. Nucleic Acids Res 31(1):374-8