Standard Name	MCM1 1, 2, 3
Systematic Name	YMR043W
Alias	FUN80 4
Feature Type	ORF, Verified
Description	Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes (5, 6, 7)
Name Description	MiniChromosome Maintenance 8

Chromosomal Location	ChrXIII:353871 to 354731 | ORF Map | GBrowse
	Genetic position: 35 cM

	View Computational GO annotations for MCM1
Molecular Function
Manually curated	DNA replication origin binding (IDA) RNA polymerase II activating transcription factor binding (IMP, IPI) RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription (IDA) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (IDA, IMP) RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending (IDA, IMP) RNA polymerase II repressing transcription factor binding (IDA, IPI) sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity (IDA, IPI)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	DNA replication initiation (IMP) negative regulation of arginine catabolic process by negative regulation of transcription from RNA polymerase II promoter (IMP) negative regulation of mating-type specific transcription from RNA polymerase II promoter (IMP) negative regulation of transcription from RNA polymerase II promoter (IDA, IMP) positive regulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter (IDA, IMP) positive regulation of mating-type specific transcription from RNA polymerase II promoter (IDA, IMP) positive regulation of transcription from RNA polymerase II promoter (IDA, IMP) positive regulation of transcription involved in G2/M-phase of mitotic cell cycle (IMP) regulation of mating type switching (IMP)
Cellular Component
Manually curated	nuclear chromatin (IDA)

Binding motifs	Predicted MCM1 Binding Site Locations
	CCNRATNNGG 9 [Search intergenic regions for CCNRATNNGG] TCCNNWWNNGGA 10 [Search intergenic regions for TCCNNWWNNGGA] WTWCCYAAWNNGGTAA 11 [Search intergenic regions for WTWCCYAAWNNGGTAA]
Regulatory modules	predicted: stressResponse (403, 385, 379)
Resources	ScerTF | UniProbe | YEASTRACT | YeTFaSCo

Classical genetics
conditional	colony sectoring: increased
overexpression	budding index: decreased cell cycle progression in G1 phase: arrested cellular morphology: abnormal
reduction of function	bud morphology: abnormal cell cycle progression in M phase: arrested cell size: increased chromosome/plasmid maintenance: abnormal growth in exponential phase: normal rate growth in exponential phase: decreased rate pheromone-induced cell cycle arrest: decreased spindle morphology: abnormal viability: normal viability: decreased
repressible	vegetative growth: decreased
Large-scale survey
conditional	heat sensitivity: increased
null	haploinsufficient inviable
overexpression	cell cycle progression: abnormal vegetative growth: decreased rate
reduction of function	competitive fitness: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	65 total interaction(s) for 39 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 1 Affinity Capture-Western: 8 Co-crystal Structure: 2 PCA: 1 Reconstituted Complex: 14 Two-hybrid: 11
Genetic Interactions	Dosage Growth Defect: 2 Dosage Rescue: 8 Phenotypic Enhancement: 2 Phenotypic Suppression: 6 Synthetic Lethality: 3 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:353871 to 354731 | ORF Map | GBrowse
	Genetic position: 35 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..861 353871..354731 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004646