MIH1/YMR036C Summary

MIH1 BASIC INFORMATION

Standard Name	MIH1 1
Systematic Name	YMR036C
Feature Type	ORF, Verified
Description	Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25 (1, 2)
Name Description	Mitotic Inducer Homolog 1

GO Annotations	All MIH1 GO evidence and references
	View Computational GO annotations for MIH1
Molecular Function
Manually curated	protein tyrosine phosphatase activity (ISS)
Biological Process
Manually curated	G2/M transition of mitotic cell cycle (IGI, IMP, ISS) regulation of cyclin-dependent protein kinase activity (IGI, IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Mutant Phenotype	All MIH1 Phenotype details and references
Classical genetics
null	cell cycle progression in G2 phase: increased duration cell size: increased
Large-scale survey
null	resistance to calcium dichloride: decreased viable

Interactions	MIH1 All interactions details and references
	45 total interaction(s) for 36 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 1 Biochemical Activity: 14 Protein-RNA: 1 Two-hybrid: 4
Genetic Interactions	Phenotypic Enhancement: 11 Phenotypic Suppression: 3 Synthetic Lethality: 3 Synthetic Rescue: 3

Sequence Information

ChrXIII:343519 to 341855 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1665	343519..341855	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004639

MIH1 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for MIH1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MIH1]

1)	Russell P, et al. (1989) Conservation of mitotic controls in fission and budding yeasts. Cell 57(2):295-303
2)	Sia RA, et al. (1996) Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast. Mol Biol Cell 7(11):1657-66

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