UFO1/YML088W Summary Help

Standard Name UFO1 1
Systematic Name YML088W
Feature Type ORF, Verified
Description F-box receptor protein; subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation (1)
Name Description UV-F-box-HO 1
Chromosomal Location
ChrXIII:92235 to 94241 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All UFO1 GO evidence and references
  View Computational GO annotations for UFO1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
repressible
Resources
78 total interaction(s) for 40 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 20
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 23
  • Biochemical Activity: 2
  • Co-purification: 1
  • Reconstituted Complex: 10
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Growth Defect: 5
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Positive Genetic: 5
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 668
Molecular Weight (Da) 76,859
Isoelectric Point (pI) 5.1
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:92235 to 94241 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2007 92235..94241 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004553
References cited on this page View Complete Literature Guide for UFO1
1) Kaplun L, et al.  (2003) DNA damage response-mediated degradation of Ho endonuclease via the ubiquitin system involves its nuclear export. J Biol Chem 278(49):48727-34