CMP2/YML057W Summary Help

Standard Name CMP2 1
Systematic Name YML057W
Alias CNA2 2
Feature Type ORF, Verified
Description Calcineurin A; one isoform (the other is Cna1p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CMP2 has a paralog, CNA1, that arose from the whole genome duplication (3, 4, 5, 6, 7)
Name Description CalModulin binding Protein 1
Chromosomal Location
ChrXIII:160180 to 161994 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CMP2 GO evidence and references
  View Computational GO annotations for CMP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
unspecified
Resources
79 total interaction(s) for 51 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 26
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 3
  • Biochemical Activity: 1
  • Co-purification: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 3
  • Negative Genetic: 9
  • Positive Genetic: 14
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 4
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 604
Molecular Weight (Da) 68,527
Isoelectric Point (pI) 6.32
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:160180 to 161994 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1815 160180..161994 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004521
References cited on this page View Complete Literature Guide for CMP2
1) Liu Y, et al.  (1991) The Saccharomyces cerevisiae genes (CMP1 and CMP2) encoding calmodulin-binding proteins homologous to the catalytic subunit of mammalian protein phosphatase 2B. Mol Gen Genet 227(1):52-9
2) Cyert MS, et al.  (1991) Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase. Proc Natl Acad Sci U S A 88(16):7376-80
3) Garrett-Engele P, et al.  (1995) Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase. Mol Cell Biol 15(8):4103-14
4) Cyert MS  (2003) Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stress. Biochem Biophys Res Commun 311(4):1143-50
5) Rusnak F and Mertz P  (2000) Calcineurin: form and function. Physiol Rev 80(4):1483-521
6) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
7) O'Donnell AF, et al.  (2013) A Calcineurin-dependent Switch Controls the Trafficking Function of a-Arrestin Aly1/Art6. J Biol Chem 288(33):24063-80