IMD4/YML056C Summary

IMD4 BASIC INFORMATION

Standard Name	IMD4 1
Systematic Name	YML056C
Feature Type	ORF, Verified
Description	Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed (2)
Name Description	IMP Dehydrogenase 1

GO Annotations	All IMD4 GO evidence and references
	View Computational GO annotations for IMD4
Molecular Function
Manually curated	IMP dehydrogenase activity (ISS)
Biological Process
Manually curated	biological_process unknown (ND)
Cellular Component
High-throughput	cytoplasm (IDA)

Pathways	de novo biosynthesis of purine nucleotides superpathway of histidine, purine, and pyrimidine biosynthesis superpathway of purine biosynthesis and salvage pathways

Mutant Phenotype	All IMD4 Phenotype details and references
Classical genetics
null	GFP-Rap1 distribution: abnormal resistance to mycophenolic acid: normal viable
overexpression	resistance to 6-azauracil: increased
Large-scale survey
null	viable

Interactions	IMD4 All interactions details and references
	71 total interaction(s) for 55 unique genes/features.
Physical Interactions	Affinity Capture-MS: 59 Affinity Capture-RNA: 1 Co-purification: 1 PCA: 4 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Synthetic Growth Defect: 1

Sequence Information

ChrXIII:164176 to 162194 | |

Note: this feature is encoded on the Crick strand.

This feature contains embedded feature(s): SNR54

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..460	164176..163717	1996-07-31	1996-07-31
Intron	461..868	163716..163309	1996-07-31	1996-07-31
CDS	869..1983	163308..162194	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004520

IMD4 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for IMD4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for IMD4]

1)	Escobar-Henriques M and Daignan-Fornier B (2001) Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J Biol Chem 276(2):1523-30
2)	Hyle JW, et al. (2003) Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast. J Biol Chem 278(31):28470-8

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