Standard Name	CGI121 1
Systematic Name	YML036W
Feature Type	ORF, Verified
Description	Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification (1, 2, 3)

Chromosomal Location	ChrXIII:205642 to 206293 | ORF Map | GBrowse

	View Computational GO annotations for CGI121
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	positive regulation of transcription from RNA polymerase II promoter (IPI) telomere maintenance (IGI, IMP)
Cellular Component
Manually curated	EKC/KEOPS complex (IDA)

Large-scale survey
null	cell cycle progression in G1 phase: increased duration competitive fitness: decreased fermentative growth: decreased rate heat sensitivity: increased resistance to amitrole: decreased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to quinine: decreased resistance to L-canavanine: increased resistance to cycloheximide: decreased resistance to acrolein: decreased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	33 total interaction(s) for 15 unique genes/features.
Physical Interactions	Affinity Capture-MS: 20 Affinity Capture-Western: 1 Far Western: 2 Reconstituted Complex: 1
Genetic Interactions	Dosage Lethality: 1 Phenotypic Suppression: 1 Positive Genetic: 1 Synthetic Lethality: 2 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:205642 to 206293 | ORF Map | GBrowse
Last Update	Coordinates: 2007-07-10 | Sequence: 2007-07-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..456 205642..206097 2007-07-10 2007-07-10 Intron 457..562 206098..206203 2007-07-10 2007-07-10 CDS 563..652 206204..206293 2007-07-10 2007-07-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (457 - 562)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004500