Standard Name	YOX1 1
Systematic Name	YML027W
Feature Type	ORF, Verified
Description	Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	Yeast homeobOX 1

Chromosomal Location	ChrXIII:221406 to 222563 | ORF Map | GBrowse

	View Computational GO annotations for YOX1
Molecular Function
Manually curated	RNA polymerase II regulatory region sequence-specific DNA binding (IDA, IMP) RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription (IMP, IPI)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	negative regulation of transcription involved in G1 phase of mitotic cell cycle (IGI, IMP)
Cellular Component
Manually curated	nuclear chromatin (IDA) nucleus (IC, IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Binding motifs	Predicted YOX1 Binding Site Locations
	YAATTA 2 [Search intergenic regions for YAATTA] YTAATTAR 6 [Search intergenic regions for YTAATTAR] YTAATTW 7 [Search intergenic regions for YTAATTW]
Resources	ScerTF | UniProbe | YEASTRACT | YeTFaSCo

Classical genetics
null	viable
overexpression	cell cycle progression in S phase: delayed cell cycle progression in S phase: increased duration chromosome/plasmid maintenance: decreased Mcm4p distribution: abnormal vegetative growth: decreased
Large-scale survey
null	competitive fitness: decreased filamentous growth: decreased invasive growth: absent resistance to benzo[a]pyrene: increased resistance to benzo[a]pyrene: decreased starvation resistance: decreased utilization of carbon source: absent vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	32 total interaction(s) for 29 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Biochemical Activity: 2 Protein-RNA: 1 Reconstituted Complex: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 20 Positive Genetic: 2 Synthetic Growth Defect: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:221406 to 222563 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1158 221406..222563 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004489